Chronic Myelomonocytic Leukemia Treatment in India. Chronic myelomonocytic leukemia (CMML) is a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) as it shares features of both dysplasia and proliferative neoplasia. It is characterized by a sustained increase of monocytes that have no known reactive cause. Although many cases do show dysplasia in the granulocytic component of the bone marrow, other cases of CMML may only show proliferative features. Most patients present with fatigue, weight loss, night sweats, and fevers. Patients typically have an increased white count (MPN feature), although a subset does present with normal or only modestly elevated leukocytes.